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Glioma is the most common type of invasive malignant tumor in central nervous system (CNS), accounting for 65% of primary intracranial tumors (1,2). In 2016, World Health Organization (WHO) classified glioma into grade I-IV histologically according to the degree of malignancy. Grade IV is glioblastoma (GBM), which is highly invasive with poor prognosis (3). Despite the complete resection of GBM plus postoperative radiotherapy and chemotherapy, the median PFS and OS is not optimistic (4). Although certain prognostic factors for GBM have been reported (5,6), the guiding function to the current treatment is limited, which warranted the new prognostic factors to be constantly Original Article

Serum albumin levels and serum albumin-globulin ratio are associated with poor prognosis in glioblastoma