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Among malignant tumors, hepatocellular carcinoma (HCC) is the sixth most common in terms of occurrence and cancer-related death (1,2). Typically, HCC treatment involves surgery-based comprehensive therapies. However, the HCC prognosis remains poor, even following surgical resection, as there is a high frequency of recurrence and cancer cell migration into adjunct normal tissues (3,4). The 5-year postoperative recurrence rate of HCC is >60%, mainly due to recurrence and chemoresistance (5,6). Therefore, novel molecular mechanisms must be developed to treat tumor growth and migration. Micro-ribonucleic acids (miRNAs) are 19–22 nucleotides long and noncoding, and induce mRNA degradation by binding of the target mRNA 3’-untranslated region (UTR) or inhibiting translation (7). Studies have found Original Article

miR-378a-5p improved the prognosis and suppressed the progression of hepatocellular carcinoma by targeting the VEGF pathway