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Department of Pathology, Department of Thoracic Surgery, the Second Xiangya Hospital of Central South University, Changsha 410000, China; Institute of Foreign Languages, Central South University, Changsha 410000, China; Institute of Transformation Medicine Affiliated to Hunan Yearth Biotechnology Co., Ltd. Changsha 410000, China Contributions: (I) Conception and design: W Hu; (II) Administrative support: Y Wang; (III) Provision of study materials or patients: HX Liang; (IV) Collection and assembly of data: M Zou, BB Zou; (V) Data analysis and interpretation: M Zou, BB Zou; (VI) Manuscript writing: All authors; (VII) Final approval of manuscript: All authors. Correspondence to: Wen Hu. Department of Thoracic Surgery, the Second Xiangya Hospital of Central South University, No. 139 of Renmin Road, Changsha 410000, China. Email: huwen@csu.edu.cn.

FOXO3/TRIM22 axis abated the antitumor effect of gemcitabine in non-small cell lung cancer via autophagy induction