Quantitative ubiquitylome analysis and crosstalk with proteome/acetylome analysis identified novel pathways and targets of perifosine treatment in neuroblastoma | Zendy

Min Jiang | Zendy; Zhongyan Hua | Zendy; Yudi Dong | Zendy; Zhihui Liu | Zendy; Carol J. Thiele | Zendy; Zhijie Li | Zendy

Open Access

Quantitative ubiquitylome analysis and crosstalk with proteome/acetylome analysis identified novel pathways and targets of perifosine treatment in neuroblastoma

Author(s) -

Min Jiang,

Zhongyan Hua,

Yudi Dong,

Zhihui Liu,

Carol J. Thiele,

Zhijie Li

Publication year - 2018

Publication title -

translational cancer research

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.254

H-Index - 30

eISSN - 2219-6803

pISSN - 2218-676X

DOI - 10.21037/tcr.2018.11.30

Subject(s) - kegg , stable isotope labeling by amino acids in cell culture , proteome , acetylation , biology , lysine , crosstalk , ubiquitin , signal transduction , quantitative proteomics , computational biology , biochemistry , proteomics , microbiology and biotechnology , transcriptome , chemistry , gene , gene expression , physics , amino acid , optics

Perifosine, is a third generation alkylphospholipid analog which has promising anti-tumor efficacy in clinical trials of refractory/recurrent neuroblastoma (NB). However, perifosine's mechanism of action remains unclear. Previously, we have shown that perifosine changes global proteome and acetylome profiles in NB.

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