Role of the androgen signaling axis in genitourinary malignancies | Zendy

Brian Shinder | Zendy; Adam Shupe | Zendy; Geun Taek Lee | Zendy; Mark N. Stein | Zendy; Isaac Yi Kim | Zendy; Eric A. Singer | Zendy

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Role of the androgen signaling axis in genitourinary malignancies

Author(s) -

Brian Shinder,

Adam Shupe,

Geun Taek Lee,

Mark N. Stein,

Isaac Yi Kim,

Eric A. Singer

Publication year - 2018

Publication title -

translational cancer research

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.254

H-Index - 30

eISSN - 2219-6803

pISSN - 2218-676X

DOI - 10.21037/tcr.2018.03.41

Subject(s) - genitourinary system , androgen receptor , prostate cancer , medicine , prostate , androgen , disease , cancer research , bladder cancer , cancer , oncology , bioinformatics , biology , hormone

As we learn more about the molecular biology of genitourinary malignancies, novel therapeutic strategies can be developed. This is especially crucial for prostate, renal, and bladder cancer, where mortality rates remain high especially in advanced disease states. The androgen signaling axis and the androgen receptor (AR) are areas that are actively being explored for their role in these diseases. Although long been associated with prostate cancer development and progression, the role of AR in renal cell carcinoma (RCC) and bladder cancer is becoming recognized as well. This review will highlight the current research into the role of the androgen signaling axis in genitourinary malignancies and how this pathway is being used to expand our therapeutic armamentarium.

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