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Department of Orthopedics, Shanghai University of Medicine & Health Sciences Affiliated Zhoupu Hospital, Shanghai, China; Department of Orthopedics, Shanghai Public Health Clinical Center, Shanghai, China Contributions: (I) Conception and design: Z Xu, X Zhou; (II) Administrative support: Z Xu, X Zhou; (III) Provision of study materials or patients: Z Xu, X Zhou, Z Gao; (IV) Collection and assembly of data: Z Xu, X Zhou, Z Gao; (V) Data analysis and interpretation: All authors; (VI) Manuscript writing: All authors; (VII) Final approval of manuscript: All authors. These authors contributed equally to this work. Correspondence to: Zhenchao Gao, MD. Department of Orthopedics, Shanghai Public Health Clinical Center, No. 2901, Caolang Road, Jinshan District, Shanghai, China. Email: gaozhenchao1680@163.com.

Mesenchymal stem cell-derived exosomes carrying microRNA-150 suppresses the proliferation and migration of osteosarcoma cells via targeting IGF2BP1