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Despite improvements in medical care, tumor remains the second leading cause of death worldwide (1). Combination of chemotherapy with cytotoxic drugs is a promising strategy for the treatment of several malignant tumors. Paclitaxel is a widely used antineoplastic agent that promotes assembly of microtubules, inhibits tubulin disassembly, and blocks cell cycling at the G2/M stage. Compared with the solvent-based paclitaxel, nanoparticle albumin-bound paclitaxel (nab-paclitaxel) does not require special infusion devices due to different paclitaxel carriers, without necessity of pre-treatment, associating with a lower Original Article

translational cancer research

Investigating the relationship between secreted protein acidic and rich in cysteine expression level and therapeutic efficacy of nab-paclitaxel: a meta-analysis