Open AccessInvestigating the relationship between secreted protein acidic and rich in cysteine expression level and therapeutic efficacy of nab-paclitaxel: a meta-analysis
Author(s) -
Xiaobo Zhou,
Lan Zhang,
Caihang Qierang,
Min Huang,
Xin Yang,
Liangang Li,
Jun Jiang
Publication year - 2021
Publication title -
translational cancer research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.254
H-Index - 30
eISSN - 2219-6803
pISSN - 2218-676X
DOI - 10.21037/tcr-20-3045
Subject(s) - osteonectin , paclitaxel , stromal cell , nab paclitaxel , medicine , cancer research , oncology , cell , meta analysis , cancer , chemistry , biochemistry , alkaline phosphatase , osteocalcin , enzyme
Despite improvements in medical care, tumor remains the second leading cause of death worldwide (1). Combination of chemotherapy with cytotoxic drugs is a promising strategy for the treatment of several malignant tumors. Paclitaxel is a widely used antineoplastic agent that promotes assembly of microtubules, inhibits tubulin disassembly, and blocks cell cycling at the G2/M stage. Compared with the solvent-based paclitaxel, nanoparticle albumin-bound paclitaxel (nab-paclitaxel) does not require special infusion devices due to different paclitaxel carriers, without necessity of pre-treatment, associating with a lower Original Article
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