English (United Kingdom)

https://curated-unify.zendy.io/wp-json/zendy-region/v1/featured_content/oa?rat=en

https://curated-unify.zendy.io/wp-json/zendy-region/v1/highlighted_journal/

Global: Zendy Plus annual

Presents the access of premium content as premium feature

Premium Content

Presents the keyphrase highlighting as premium feature

Keyphrase Highlighting

Presents the summarisation as premium feature

Summarisation

Insights

Presents the pdf analysis as premium feature

PDF Analysis

Presents the zaia usage as premium feature

ZAIA

Global: Zendy Plus monthly

Global: Zendy Tools annual

Global: Zendy Tools monthly

Global: Zendy Free Plan

ACE stands for “A Phase III Trial of Chidamide in Combination with Exemestane in Patients with Hormone Receptor-Positive Advanced Breast Cancer”. Chidamide, or by its International Nonproprietary Name (INN), tucidinostat, is an oral subtype-selective histone deacetylase (HDAC) inhibitor with unique epigenetic modulating mechanisms for anti-cancer treatment. Chidamide has been approved in China for the indications of relapsed or refractory peripheral T-cell lymphoma, and hormone receptor-positive (HR+) advanced breast cancer. In the current review, epigenetic regulations and HDACs, the potential roles of epigenetic aberrations in disease progression and resistance to endocrine therapy in HR+ breast cancer, and the development of HDAC inhibitors as a promising therapeutic strategy in the field are overlooked. Then the review focuses on the ACE study in its rationale, trial design and results that led to the first-in-disease approval of chidamide in the epigenetic modulating drug class in breast cancer.

translational breast cancer research

Why ACE—overview of the development of the subtype-selective histone deacetylase inhibitor chidamide in hormone receptor positive advanced breast cancer