Open AccessThe emerging role of PTBP1 in human cancer: novel prognostic factor in non-muscle invasive bladder cancer
Author(s) -
Pamela Bielli,
Savino M. Di Stasi,
Claudio Sette
Publication year - 2018
Publication title -
translational andrology and urology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.721
H-Index - 27
eISSN - 2223-4691
pISSN - 2223-4683
DOI - 10.21037/tau.2018.12.01
Subject(s) - cancer , bladder cancer , cancer research , medicine , oncology , bioinformatics , biology
Alternative splicing is a sophisticated RNA processing mechanism that expands the coding potential of the genome and the proteomic complexity in higher eukaryotes. Splicing requires the recognition of the intron/exon boundaries by a large ribonucleoprotein complex, named the spliceosome, followed by intron excision and ligation of exons to yield the messenger RNA (mRNA) (1).
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