AB046. The evaluation of therapeutic efficiency of relapse prevention of alternating bladder perfusion with GEM and THP after TURBT of superficial bladder cancer

Objective To observe the therapeutic efficiency of relapse prevention of alternating bladder perfusion with GEM and THP after TURBT of superficial bladder cancer. Methods Ninety-two cases of bladder urothelial carcinoma (BUC) patients with TURBT after transurethral catheterization regularly alternating GEM and THP bladder perfusion, total time limit of 19 months after operation, respectively in 3, 6 and 12 months were followed up by cystoscope or CT. After the end of treatment, review again every 6 or 12 months according to the previous review results, for five consecutive years. Results During the five years, 23 cases of local recurrence, the recurrence rate was 26.4% (23/87), 4 cases of local recurrence and metastasis, recurrence and metastasis rate was 4.6% (4/87), 2 cases of death, mortality was 2.3% (2/87),died of the other disease not related with this one in 9 cases, 5 cases lost follow-up. Conclusions GEM and THP as the adjuvant chemotherapy drugs after TURBT of superficial bladder cancer, has significant characteristic of curative effect does with small side effects to improve prognosis, decrease recurrence and the mortality rate, may become one of the important means to improve the postoperative curative effect.