The effect of ApoE ε 4 on clinical and structural MRI markers in prodromal Alzheimer’s disease | Zendy

Chunhua Zhang | Zendy; Min Kong | Zendy; Hongchun Wei | Zendy; Hua Zhang | Zendy; Guozhao Ma | Zendy; Maowen Ba | Zendy

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The effect of ApoE ε 4 on clinical and structural MRI markers in prodromal Alzheimer’s disease

Author(s) -

Chunhua Zhang,

Min Kong,

Hongchun Wei,

Hua Zhang,

Guozhao Ma,

Maowen Ba

Publication year - 2020

Publication title -

quantitative imaging in medicine and surgery

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.766

H-Index - 21

eISSN - 2223-4292

pISSN - 2223-4306

DOI - 10.21037/qims.2020.01.14

Subject(s) - disease , medicine , apolipoprotein e , pathology , bioinformatics , biology

Apolipoprotein E (ApoE) ε 4 has been identified as the strongest genetic risk factor for Alzheimer's disease (AD). However, the importance of ApoE ε 4 on clinical and biological heterogeneity of AD is still to be determined, particularly at the prodromal stage. Here, we evaluate the association of ApoE ε 4 with clinical cognition and neuroimaging regions in mild cognitive impairment (MCI) participants based on the AT (N) system, which is increasingly essential for developing a precise assessment of AD.

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