Kinetic modeling and analysis of dynamic bioluminescence imaging of substrates administered by intraperitoneal injection | Zendy

Yunpeng Dai | Zendy; Duofang Chen | Zendy; Guodong Wang | Zendy; Jipeng Yin | Zendy; Yonghua Zhan | Zendy; Kaichun Wu | Zendy; Jimin Liang | Zendy; Xueli Chen | Zendy

Open Access

Kinetic modeling and analysis of dynamic bioluminescence imaging of substrates administered by intraperitoneal injection

Author(s) -

Yunpeng Dai,

Duofang Chen,

Guodong Wang,

Jipeng Yin,

Yonghua Zhan,

Kaichun Wu,

Jimin Liang,

Xueli Chen

Publication year - 2020

Publication title -

quantitative imaging in medicine and surgery

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.766

H-Index - 21

eISSN - 2223-4292

pISSN - 2223-4306

DOI - 10.21037/qims.2020.01.01

Subject(s) - bioluminescence , intraperitoneal injection , bioluminescence imaging , computer science , pathology , medicine , chemistry , pharmacology , biochemistry , luciferase , gene , transfection

Bioluminescence imaging (BLI) has been found to have diverse applications in the life sciences and medical research due to its ease of use and high sensitivity. From kinetics analysis, dynamic imaging studies have significant advantages for diagnosis when compared to traditional static imaging studies. This work focuses on modeling and quantitatively analyzing the dynamic data produced from the intraperitoneal (IP) injection of D-luciferin in longitudinal BLI, aiming to provide a powerful tool for monitoring the growth of tumors.

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