Open AccessCollagen deposition in the liver is strongly and positively associated with T1rho elongation while fat deposition is associated with T1rho shortening: an experimental study of methionine and choline-deficient (MCD) diet rat model
Author(s) -
Feng Zhao,
Nan Zhou,
Jili Wang,
Hua Zhou,
Zou Liqiu,
Weixiang Zhong,
Jian He,
Cunjing Zheng,
Senxiang Yan,
Yì Wáng
Publication year - 2020
Publication title -
quantitative imaging in medicine and surgery
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.766
H-Index - 21
eISSN - 2223-4292
pISSN - 2223-4306
DOI - 10.21037/qims-20-651
Subject(s) - steatohepatitis , fibrosis , h&e stain , inflammation , fatty liver , steatosis , pathology , medicine , choline , endocrinology , methionine , masson's trichrome stain , staining , chemistry , biochemistry , disease , amino acid
A number of questions concerning the histological mechanism of elongated T1rho in liver fibrosis remain unanswered. Using a rat model of non-alcoholic fatty liver disease (NAFLD) induced with methionine and choline-deficient (MCD) diet, the primary aim of this study is to clarify whether collagen deposition per se causes liver T1rho elongation.
Accelerating Research
Robert Robinson Avenue,
Oxford Science Park, Oxford
OX4 4GP, United Kingdom
Address
John Eccles HouseRobert Robinson Avenue,
Oxford Science Park, Oxford
OX4 4GP, United Kingdom