Ectosome biogenesis and release processes observed by using live-cell dynamic imaging in mammalian glial cells
Author(s) -
Mengjiao Sun,
Xiufen Xue,
Lingyun Li,
Dandan Xu,
Shihe Li,
Shengwen Calvin Li,
Qingning Su
Publication year - 2021
Publication title -
quantitative imaging in medicine and surgery
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.766
H-Index - 21
eISSN - 2223-4292
pISSN - 2223-4306
DOI - 10.21037/qims-20-1015
Subject(s) - biogenesis , neuroscience , brain cell , cell , microbiology and biotechnology , biology , computer science , biochemistry , gene
Ectosomes are recognized as shedding from the plasma membranes into the extracellular environment. Recent research has demonstrated that ectosomes are surrounded by phospholipid membranes containing lipid rafts and caveolae. Some ectosomes contain cytokines in the lumen and have high levels of phosphatidylserine exposed to the outer membrane. Intracellular vesicles share both characters with ectosomes. Why the plasma membrane-derived ectosomes have the same characteristics as intracellular vesicles remain largely unknown.
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