Phenotypic and genotypic characterization of levofloxacin- and moxifloxacin-resistant Mycobacterium tuberculosis clinical isolates in southern China | Zendy

H. M. Adnan Hameed | Zendy; Yaoju Tan | Zendy; Md. Mahmudul Islam | Zendy; Lingmin Guo | Zendy; Chiranjibi Chhotaray | Zendy; Shuai Wang | Zendy; Xiaogang Li | Zendy; Yamin Gao | Zendy; Shouyong Tan | Zendy; Wing Wai Yew | Zendy; Nanshan Zhong | Zendy; Jianxiong Liu | Zendy; Tianyu Zhang | Zendy

Open Access

Phenotypic and genotypic characterization of levofloxacin- and moxifloxacin-resistant Mycobacterium tuberculosis clinical isolates in southern China

Author(s) -

H. M. Adnan Hameed,

Yaoju Tan,

Md. Mahmudul Islam,

Lingmin Guo,

Chiranjibi Chhotaray,

Shuai Wang,

Xiaogang Li,

Yamin Gao,

Shouyong Tan,

Wing Wai Yew,

Nanshan Zhong,

Jianxiong Liu,

Tianyu Zhang

Publication year - 2019

Publication title -

journal of thoracic disease

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.682

H-Index - 60

eISSN - 2077-6624

pISSN - 2072-1439

DOI - 10.21037/jtd.2019.11.03

Subject(s) - dna gyrase , moxifloxacin , levofloxacin , genotype , microbiology and biotechnology , mycobacterium tuberculosis , medicine , ofloxacin , multiple drug resistance , drug resistance , virology , biology , tuberculosis , antibiotics , gene , genetics , ciprofloxacin , escherichia coli , pathology

Levofloxacin (LVX) and Moxifloxacin (MXF) are the cornerstones for treatment of multidrug-resistant tuberculosis (MDR-TB). China is one of the highest MDR- and fluoroquinolones (FQ)-resistant TB burdens countries. DNA gyrase encoded by gyr genes is the main target of FQ in Mycobacterium tuberculosis (MTB). The prevalence and molecular characterization of LVX- and MXF-resistant MTB strains from southern China were examined in this study.

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