Extracellular mitochondrial DNA promote NLRP3 inflammasome activation and induce acute lung injury through TLR9 and NF-κB | Zendy

Guannan Wu | Zendy; Qingqing Zhu | Zendy; Junli Zeng | Zendy; Xiaoling Gu | Zendy; Yingying Miao | Zendy; Wujian Xu | Zendy; Tangfeng Lv | Zendy; Yong Song | Zendy

Open Access

Extracellular mitochondrial DNA promote NLRP3 inflammasome activation and induce acute lung injury through TLR9 and NF-κB

Author(s) -

Guannan Wu,

Qingqing Zhu,

Junli Zeng,

Xiaoling Gu,

Yingying Miao,

Wujian Xu,

Tangfeng Lv,

Yong Song

Publication year - 2019

Publication title -

journal of thoracic disease

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.682

H-Index - 60

eISSN - 2077-6624

pISSN - 2072-1439

DOI - 10.21037/jtd.2019.10.26

Subject(s) - inflammasome , inflammation , caspase 1 , mitochondrial dna , tlr9 , microbiology and biotechnology , extracellular , tumor necrosis factor alpha , nf κb , apoptosis , p38 mitogen activated protein kinases , caspase 3 , biology , mapk/erk pathway , medicine , immunology , programmed cell death , kinase , biochemistry , gene expression , gene , dna methylation

Extracellular mitochondrial DNA (mtDNA) was demonstrated to be capable of inducing pulmonary inflammation through TLR9 while its role in NLRP3 inflammation activation remains unknown.

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