Open AccessRole of miRNA-181a-2-3p in cadmium-induced inflammatory responses of human bronchial epithelial cells
Author(s) -
Jee-Young Kim,
Dong Yeop Kim,
Hye-Ryeon Heo,
Sun Shim Choi,
SeokHo Hong,
Woo Jin Kim
Publication year - 2019
Publication title -
journal of thoracic disease
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.682
H-Index - 60
eISSN - 2077-6624
pISSN - 2072-1439
DOI - 10.21037/jtd.2019.07.55
Subject(s) - inflammation , copd , pathogenesis , microrna , downregulation and upregulation , medicine , immunology , gene silencing , relb , gene knockdown , biology , gene , nfkb1 , transcription factor , biochemistry
Inflammation is an important priming event in the pathogenesis of pulmonary diseases, including chronic obstructive pulmonary disease (COPD). Increasing evidence indicates that microRNAs (miRNAs) contribute to the pathogenesis of COPD by regulating inflammatory response. Therefore, it is necessary to investigate novel molecular targets in COPD without any validation in COPD samples in airway inflammation. The aim of our study is to reveal novel miRNAs that can influence molecular targets for COPD and to examine the underlying mechanism in airway inflammation.
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