Outcomes of patients with advanced non-small cell lung cancer and airway obstruction treated with photodynamic therapy and non-photodynamic therapy ablation modalities | Zendy

Ravishankar Jayadevappa | Zendy; Sumedha Chhatre | Zendy; Harmik J. Soukiasian | Zendy; Septimiu Murgu | Zendy

Open Access

Outcomes of patients with advanced non-small cell lung cancer and airway obstruction treated with photodynamic therapy and non-photodynamic therapy ablation modalities

Author(s) -

Ravishankar Jayadevappa,

Sumedha Chhatre,

Harmik J. Soukiasian,

Septimiu Murgu

Publication year - 2019

Publication title -

journal of thoracic disease

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.682

H-Index - 60

eISSN - 2077-6624

pISSN - 2072-1439

DOI - 10.21037/jtd.2019.04.60

Subject(s) - medicine , radiation therapy , hazard ratio , brachytherapy , photodynamic therapy , lung cancer , chemotherapy , stage (stratigraphy) , proportional hazards model , airway , oncology , surgery , cancer , radiology , confidence interval , chemistry , organic chemistry , paleontology , biology

Non-small cell lung cancer (NSCLC) patients with central airway obstruction (CAO) may have better survival on systemic therapy if the airway patency is successfully restored by bronchoscopic interventions. It remains unclear which therapeutic bronchoscopic modality [laser, stenting, external beam radiation, brachytherapy and photodynamic therapy (PDT)] used for restoring airway patency positively affects outcomes in these patients. We analyzed the effectiveness of PDT in terms of mortality, and time to subsequent treatments in patients with stage III and IV NSCLC.

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