Platelet mitochondrial cytochrome c oxidase subunit I variants with benzene poisoning | Zendy

Dianpeng Wang | Zendy; Xiangli Yang | Zendy; Yanfang Zhang | Zendy; Dafeng Lin | Zendy; Paimao Li | Zendy; Zhiming Zhang | Zendy; Xianqing Huang | Zendy; Dayong Gu | Zendy; Jacky Loo | Zendy

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Platelet mitochondrial cytochrome c oxidase subunit I variants with benzene poisoning

Author(s) -

Dianpeng Wang,

Xiangli Yang,

Yanfang Zhang,

Dafeng Lin,

Paimao Li,

Zhiming Zhang,

Xianqing Huang,

Dayong Gu,

Jacky Loo

Publication year - 2018

Publication title -

journal of thoracic disease

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.682

H-Index - 60

eISSN - 2077-6624

pISSN - 2072-1439

DOI - 10.21037/jtd.2018.11.82

Subject(s) - cytochrome c oxidase , medicine , protein subunit , platelet , oxidase test , cytochrome b , mitochondrion , bioinformatics , biochemistry , enzyme , mitochondrial dna , biology , gene

Chronic benzene poisoning (CBP) is one of the most common chronic occupational poisoning which is associated with mitochondrial oxidative damage, and lead to increasing risk of respiratory diseases such as lung cancer. Cytochrome c oxidase subunit I (COI) is one of the key enzymes that plays an important role in oxidative damage regulation by eliminating reactive oxygen species (ROS). This study investigated the relationship between COI gene variants and the risk of CBP.

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