High CCR4 expression in the tumor microenvironment is a poor prognostic indicator in lung adenocarcinoma | Zendy

Takahiro Karasaki | Zendy; Guangliang Qiang | Zendy; Masaki Anraku | Zendy; Yanbin Sun | Zendy; Aya ShinozakiUshiku | Zendy; Eiichi Sato | Zendy; Kosuke Kashiwabara | Zendy; Kazuhiro Nagayama | Zendy; Junichi Nitadori | Zendy; Masaaki Sato | Zendy; Tomohiro Murakawa | Zendy; Kazuhiro Kakimi | Zendy; Masashi Fukayama | Zendy; Jun Nakajima | Zendy

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High CCR4 expression in the tumor microenvironment is a poor prognostic indicator in lung adenocarcinoma

Author(s) -

Takahiro Karasaki,

Guangliang Qiang,

Masaki Anraku,

Yanbin Sun,

Aya ShinozakiUshiku,

Eiichi Sato,

Kosuke Kashiwabara,

Kazuhiro Nagayama,

Junichi Nitadori,

Masaaki Sato,

Tomohiro Murakawa,

Kazuhiro Kakimi,

Masashi Fukayama,

Jun Nakajima

Publication year - 2018

Publication title -

journal of thoracic disease

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.682

H-Index - 60

eISSN - 2077-6624

pISSN - 2072-1439

DOI - 10.21037/jtd.2018.07.45

Subject(s) - medicine , adenocarcinoma , oncology , lung cancer , proportional hazards model , tissue microarray , tumor infiltrating lymphocytes , tumor microenvironment , survival analysis , immunohistochemistry , ccr4 , multivariate analysis , immunotherapy , cancer , receptor , chemokine , chemokine receptor

Clinical trials of anti-CCR4 antibody for solid cancers with or without other immune-modulating agents including immune checkpoint blockade therapy are currently underway. However, little is known about the roles of CCR4 + lymphocytes and their prognostic impact in lung cancer. We hypothesized that high CCR4 expression in the tumor microenvironment would be associated with a poor prognosis and would act as a biomarker in lung adenocarcinoma.

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