Neurokinin 1 receptor promotes rat airway smooth muscle cell migration in asthmatic airway remodelling by enhancing tubulin expression | Zendy

Bing Wei | Zendy; Mingwei Sun | Zendy; Yunxiao Shang | Zendy; Chao Zhang | Zendy; Xu-yong Jiao | Zendy

Open Access

Neurokinin 1 receptor promotes rat airway smooth muscle cell migration in asthmatic airway remodelling by enhancing tubulin expression

Author(s) -

Bing Wei,

Mingwei Sun,

Yunxiao Shang,

Chao Zhang,

Xu-yong Jiao

Publication year - 2018

Publication title -

journal of thoracic disease

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.682

H-Index - 60

eISSN - 2077-6624

pISSN - 2072-1439

DOI - 10.21037/jtd.2018.07.114

Subject(s) - ovalbumin , airway , antagonist , blot , immunofluorescence , medicine , receptor , cell migration , endocrinology , cell , immunology , biology , anesthesia , antibody , biochemistry , immune system , gene

Airway remodelling is a major contributor to hyper-responsiveness leading to chronic asthma; however, the underlying mechanisms remain unclear. This study aimed to investigate the effects of a neurokinin 1 receptor (NK1R) antagonist (WIN62577) on the migration of airway smooth muscle cells (ASMCs) and the expression of NK1R and alpha-tubulin in airway remodelling using young rats with asthma.

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