New dynamic viewing of mast cells in pulmonary arterial hypertension (PAH): contributors or outsiders to cardiovascular remodeling | Zendy

Jian Xu | Zendy; Jingjing Wang | Zendy; Cheng-Jie Shao | Zendy; Xiaoning Zeng | Zendy; Lixiang Sun | Zendy; Hui Kong | Zendy; Weiping Xie | Zendy; Hong Wang | Zendy

Open Access

New dynamic viewing of mast cells in pulmonary arterial hypertension (PAH): contributors or outsiders to cardiovascular remodeling

Author(s) -

Jian Xu,

Jingjing Wang,

Cheng-Jie Shao,

Xiaoning Zeng,

Lixiang Sun,

Hui Kong,

Weiping Xie,

Hong Wang

Publication year - 2018

Publication title -

journal of thoracic disease

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.682

H-Index - 60

eISSN - 2077-6624

pISSN - 2072-1439

DOI - 10.21037/jtd.2018.05.59

Subject(s) - medicine , mast (botany) , pulmonary hypertension , tissue remodeling , cardiology , mast cell , inflammation , immunology

In patients with pulmonary arterial hypertension (PAH), mast cells (MCs) are extensively observed around pulmonary vessels. However, their temporal and spatial variation during PAH development remains obscure. This study investigated the dynamic evolution of MCs in lungs and right ventricles (RV) to illuminate their role in pulmonary vascular and RV remodeling.

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