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Situs inversus totalis (SIT) is an extremely rare condition where the major organs are reversed or mirrored from their usual positions. There are few reports in the literature describing thoracoscopic major surgery in patients with this unusual anomaly. Here we report a 48-year old female with two small early stage lung cancer lesions located in the apicoposterior segment of the right upper lobe and in the dorsal segment of the right lower lobe. The patient underwent a uniportal approach through a 3 cm incision and combined anatomic segmentectomies in the upper and lower lobes. The postoperative course was uneventful. This is the first report of an anatomic segmentectomy in a patient with a situs inversus condition.

Situs inversus uniportal video-assisted thoracoscopic right anatomic segmentectomy S1-S2 and S6