Calpain and spectrin breakdown products as potential biomarkers in tuberculous pleural effusion | Zendy

Ji Young Hong | Zendy; So Yeong Park | Zendy; Youngmi Kim | Zendy; Chang Youl Lee | Zendy; Myung Goo Lee | Zendy

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Calpain and spectrin breakdown products as potential biomarkers in tuberculous pleural effusion

Author(s) -

Ji Young Hong,

So Yeong Park,

Youngmi Kim,

Chang Youl Lee,

Myung Goo Lee

Publication year - 2018

Publication title -

journal of thoracic disease

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.682

H-Index - 60

eISSN - 2077-6624

pISSN - 2072-1439

DOI - 10.21037/jtd.2018.04.85

Subject(s) - medicine , calpain , spectrin , pleural effusion , pathology , biochemistry , cytoskeleton , biology , enzyme , cell

Early diagnosis of tuberculous pleural effusion (TPE) remains difficult. Calpain is a family of calcium-dependent endopeptidase that plays an important role in extracellular matrix (ECM) remodeling and collagen synthesis. The aim of this study was to explore the diagnostic value of pleural fluid angiotensin-converting enzyme (ACE), calpain-1, spectrin breakdown products (SBDP), and matrix metalloproteinase-1 (MMP-1) in TPE and malignant pleural effusion (MPE).

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