Cell free DNA analysis by SiRe® next generation sequencing panel in non small cell lung cancer patients: focus on basal setting | Zendy

Pasquale Pisapia | Zendy; Francesco Pepe | Zendy; Riccardo Smeraglio | Zendy; Maria Russo | Zendy; Danilo Rocco | Zendy; Roberta Sgariglia | Zendy; Mariantonia Nacchio | Zendy; Caterina De Luca | Zendy; Elena Vigliar | Zendy; Claudio Bellevicine | Zendy; Giancarlo Troncone | Zendy; Umberto Malapelle | Zendy

Open Access

Cell free DNA analysis by SiRe® next generation sequencing panel in non small cell lung cancer patients: focus on basal setting

Author(s) -

Pasquale Pisapia,

Francesco Pepe,

Riccardo Smeraglio,

Maria Russo,

Danilo Rocco,

Roberta Sgariglia,

Mariantonia Nacchio,

Caterina De Luca,

Elena Vigliar,

Claudio Bellevicine,

Giancarlo Troncone,

Umberto Malapelle

Publication year - 2017

Publication title -

journal of thoracic disease

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.682

H-Index - 60

eISSN - 2077-6624

pISSN - 2072-1439

DOI - 10.21037/jtd.2017.06.97

Subject(s) - medicine , sire , oncology , lung cancer , basal (medicine) , dna sequencing , focus (optics) , cell free fetal dna , computational biology , dna , bioinformatics , genetics , biology , pregnancy , fetus , prenatal diagnosis , zoology , physics , insulin , optics

Non small cell lung cancer (NSCLC) is diagnosed in most cases on small tissue samples, such as cytological preparations and histological biopsies; these limited tissue specimens may be not always sufficient for testing epidermal growth factor receptor ( EGFR ) mutations and other relevant predictive biomarkers. Cell-free DNA (cfDNA) can be used as a surrogate for EGFR mutational testing, whenever tissue is unavailable. However, the detection of gene mutations on cfDNA is challenging; in fact, the extremely low concentration of circulating tumor DNA requires the implementation of highly sensitive and validated next generation techniques.

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