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Interleukin-8 associated with chemosensitivity and poor chemotherapeutic response to gastric cancer
Author(s) -
Sirikan Limpakan,
Pattama Wongsirisin,
Supachai Yodkeeree,
Bandhuphat Chakrabandhu,
Wilaiwan Chongruksut,
Pornngarm Limtrakul
Publication year - 2019
Publication title -
journal of gastrointestinal oncology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.084
H-Index - 39
eISSN - 2219-679X
pISSN - 2078-6891
DOI - 10.21037/jgo.2019.09.02
Subject(s) - oxaliplatin , medicine , irinotecan , cisplatin , chemotherapy , chemosensitivity assay , ex vivo , cancer , oncology , gastroenterology , in vivo , pharmacology , colorectal cancer , biology , microbiology and biotechnology
Gastric cancer (GC) patients have been found to have developed chemotherapy resistance that has resulted in a lowering of their overall survival rates. Interleukin-6 (IL-6) and interleukin-8 (IL-8) could be responsible as the predictive biomarkers in monitoring drug resistance. We have developed a protocol to monitor drug treatment by testing ex vivo chemosensitivity and cytokine levels of primary gastric cultures obtained from endoscopic biopsies.

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