Frequency and prognostic significance of isocitrate dehydrogenase 1 mutations in cholangiocarcinoma: a systematic literature review | Zendy

Audra Boscoe | Zendy; Catherine Rolland | Zendy; Robin Kate Kelley | Zendy

Open Access

Frequency and prognostic significance of isocitrate dehydrogenase 1 mutations in cholangiocarcinoma: a systematic literature review

Author(s) -

Audra Boscoe,

Catherine Rolland,

Robin Kate Kelley

Publication year - 2019

Publication title -

journal of gastrointestinal oncology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.084

H-Index - 39

eISSN - 2219-679X

pISSN - 2078-6891

DOI - 10.21037/jgo.2019.03.10

Subject(s) - medicine , isocitrate dehydrogenase , systematic review , cochrane library , idh1 , medline , meta analysis , oncology , family medicine , mutation , biochemistry , gene , enzyme , chemistry , political science , law

The recognition of distinct molecular subgroups within cholangiocarcinoma (CC), along with the increasing availability of targeted therapies, suggests that further characterization of the prevalence and prognosis of frequently occurring subgroups may assist with the development of more effective treatment approaches for the management of CC. A systematic review was performed to investigate the prevalence of isocitrate dehydrogenase 1 (IDH1) mutations (mIDH1) in patients with CC, the possible clinical and prognostic significance of mIDH1, and the presence of co-mutations in tumors with mIDH1.

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