A combined treatment of curcumin, piperine, and taurine alters the circulating levels of IL-10 and miR-21 in hepatocellular carcinoma patients: a pilot study | Zendy

Hala M. Hatab | Zendy; Fatma F. Abdel Hamid | Zendy; Ahmed F. Soliman | Zendy; Tamer A. AlShafie | Zendy; Yahia Ismail | Zendy; Motawa E. El-Houseini | Zendy

Open Access

A combined treatment of curcumin, piperine, and taurine alters the circulating levels of IL-10 and miR-21 in hepatocellular carcinoma patients: a pilot study

Author(s) -

Hala M. Hatab,

Fatma F. Abdel Hamid,

Ahmed F. Soliman,

Tamer A. AlShafie,

Yahia Ismail,

Motawa E. El-Houseini

Publication year - 2019

Publication title -

journal of gastrointestinal oncology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.084

H-Index - 39

eISSN - 2219-679X

pISSN - 2078-6891

DOI - 10.21037/jgo.2019.03.07

Subject(s) - piperine , medicine , curcumin , hepatocellular carcinoma , pharmacology , taurine , biochemistry , chemistry , amino acid

Investigating and evaluating possible alternative therapeutic strategies to control hepatocellular carcinoma (HCC) is a critical need because of its high prevalence and being one of the most lethal cancers. Curcumin and taurine showed potent anti-tumor activities in pre-clinical and clinical studies by targeting multiple pathways. Thus, this study was designed to assess the effect of a combined treatment consisted of curcumin, piperine, and taurine on circulating levels of interleukin-10 (IL-10), and microRNAs miR-141 and miR-21.

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