Circulating TGF-β1 as the potential epithelial mesenchymal transition-biomarker for diagnosis of cholangiocarcinoma | Zendy

Phongsaran Kimawaha | Zendy; Apinya Jusakul | Zendy; Prem Junsawang | Zendy; Watcharin Loilome | Zendy; Narong Khuntikeo | Zendy; Anchalee Techasen | Zendy

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Circulating TGF-β1 as the potential epithelial mesenchymal transition-biomarker for diagnosis of cholangiocarcinoma

Author(s) -

Phongsaran Kimawaha,

Apinya Jusakul,

Prem Junsawang,

Watcharin Loilome,

Narong Khuntikeo,

Anchalee Techasen

Publication year - 2020

Publication title -

journal of gastrointestinal oncology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.084

H-Index - 39

eISSN - 2219-679X

pISSN - 2078-6891

DOI - 10.21037/jgo.2019.01.03

Subject(s) - medicine , epithelial–mesenchymal transition , biomarker , mesenchymal stem cell , transforming growth factor , pathology , cancer research , oncology , cancer , metastasis , biochemistry , chemistry

Cholangiocarcinoma (CCA) is a malignant tumor arising from bile duct epithelium. The oncogenic risk factor is infection by the liver fluke, Opisthorchis viverrini (Ov). One of key mechanism in the development of CCA is epithelial mesenchymal transition (EMT). We aimed to investigate the expression of EMT-related proteins namely, E-cadherin, TGF-β1 and BMP-7 in CCA tissues, to determine the level of candidate EMT-related protein, and to examine whether there were significant correlations with clinicopathological data in sera of CCA patients compared with normal groups.

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