Hypoxia imaging in upper gastrointestinal tumors and application to radiation therapy | Zendy

Randa Tao | Zendy; Bryan J. Ager | Zendy; Shane Lloyd | Zendy; Anna Torgeson | Zendy; Michelle Denney | Zendy; David K. Gaffney | Zendy; Jordan Kharofa | Zendy; Steven H. Lin | Zendy; Albert C. Koong | Zendy; Yoshimi Anzai | Zendy; John M. Hoffman | Zendy

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Hypoxia imaging in upper gastrointestinal tumors and application to radiation therapy

Author(s) -

Randa Tao,

Bryan J. Ager,

Shane Lloyd,

Anna Torgeson,

Michelle Denney,

David K. Gaffney,

Jordan Kharofa,

Steven H. Lin,

Albert C. Koong,

Yoshimi Anzai,

John M. Hoffman

Publication year - 2018

Publication title -

journal of gastrointestinal oncology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.084

H-Index - 39

eISSN - 2219-679X

pISSN - 2078-6891

DOI - 10.21037/jgo.2018.09.15

Subject(s) - medicine , hypoxia (environmental) , radiation therapy , tumor hypoxia , radiology , pathology , oncology , chemistry , organic chemistry , oxygen

Survival for upper gastrointestinal tumors remains poor, likely in part due to treatment resistance associated with intratumoral hypoxia. In this review, we highlight advances in nuclear medicine imaging that allow for characterization of in vivo tumor hypoxia in esophageal, pancreatic, and liver cancers. Strategies for adaptive radiotherapy in upper gastrointestinal tumors are proposed that would apply information gained through hypoxia imaging to the creation of personalized radiotherapy treatment plans able to overcome hypoxia-induced treatment resistance, minimize treatment-related toxicities, and improve patient outcomes.

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