Ampullary and pancreatic adenocarcinoma—a comparative study | Zendy

Marwa Ferchichi | Zendy; Raja Jouini | Zendy; Wafa Koubâa | Zendy; Fatma Khanchel | Zendy; Imen Helal | Zendy; Dhafer Hadad | Zendy; N Bibani | Zendy; Aschraf ChadliDebbiche | Zendy; Ehsen BenBrahim | Zendy

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Ampullary and pancreatic adenocarcinoma—a comparative study

Author(s) -

Marwa Ferchichi,

Raja Jouini,

Wafa Koubâa,

Fatma Khanchel,

Imen Helal,

Dhafer Hadad,

N Bibani,

Aschraf ChadliDebbiche,

Ehsen BenBrahim

Publication year - 2019

Publication title -

journal of gastrointestinal oncology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.084

H-Index - 39

eISSN - 2219-679X

pISSN - 2078-6891

DOI - 10.21037/jgo.2018.09.09

Subject(s) - kras , medicine , neuroblastoma ras viral oncogene homolog , pathogenesis , pancreatic cancer , perineural invasion , stage (stratigraphy) , adenocarcinoma , oncology , gastroenterology , pancreatic ductal adenocarcinoma , colorectal cancer , cancer , pathology , cancer research , biology , paleontology

Pancreatic ductal adenocarcinoma (PDAC) and ampullary adenocarcinoma (AAC) are 2 gastrointestinal cancers that share overlapping symptoms. Although some studies have proposed the hypothesis of differences in pathogenesis and prognosis in these 2 cancers; they remain treated similarly. The classification of AAC into three subtypes [pancreatobiliary (PB), intestinal (IT) and mixed (M)] is especially crucial for the 3 axes of patients management (diagnosis, prognosis and therapy). Some studies suggest that PB subtype pathogenesis is comparable to PDAC. The objective of this study was to conduct a comparative analysis between PDAC and AAC; notably PB subtype; via mutational status analysis of 3 oncogenes (KRAS, NRAS and BRAF) hoping to consolidate AAC biology understanding.

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