Supplementation with omega fatty acids increases the mRNA expression level of PLA2G4A in patients with gastric cancer | Zendy

Donya Bazhan | Zendy; Mahmoud Shekari Khaniani | Zendy

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Supplementation with omega fatty acids increases the mRNA expression level of PLA2G4A in patients with gastric cancer

Author(s) -

Donya Bazhan,

Mahmoud Shekari Khaniani

Publication year - 2018

Publication title -

journal of gastrointestinal oncology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.084

H-Index - 39

eISSN - 2219-679X

pISSN - 2078-6891

DOI - 10.21037/jgo.2018.08.12

Subject(s) - eicosanoid , arachidonic acid , phospholipase a2 , medicine , messenger rna , gene expression , cancer , cisplatin , gene , endocrinology , gastroenterology , cancer research , biology , chemotherapy , biochemistry , enzyme

Many lines of evidence suggest that arachidonic acid (AA)-based eicosanoid signaling pathway involved in development and progression of human cancers. Cytosolic phospholipase A2-α (cPLA2α) encoded by the PLA2G4A gene acts as an upstream regulator of eicosanoid signaling pathway through providing intracellular AA. The current study aimed to evaluate the effect of omega fatty acids on mRNA expression level of PLA2G4A in patients with gastric cancer (GC) and to assess the possible relation between its expression and clinicopathological features.

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