Circulating miRNAs in patients with Barrett’s esophagus, high-grade dysplasia and esophageal adenocarcinoma | Zendy

K. V. Pavlov | Zendy; Joost Kluiver | Zendy; Coby Meijer | Zendy; Wytske Boersmavan Ek | Zendy; Frank A.E. Kruyt | Zendy; Arend Karrenbeld | Zendy; Jan H. Kleibeuker | Zendy; Frans Peters | Zendy; Anke van den Berg | Zendy

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Circulating miRNAs in patients with Barrett’s esophagus, high-grade dysplasia and esophageal adenocarcinoma

Author(s) -

K. V. Pavlov,

Joost Kluiver,

Coby Meijer,

Wytske Boersmavan Ek,

Frank A.E. Kruyt,

Arend Karrenbeld,

Jan H. Kleibeuker,

Frans Peters,

Anke van den Berg

Publication year - 2018

Publication title -

journal of gastrointestinal oncology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.084

H-Index - 39

eISSN - 2219-679X

pISSN - 2078-6891

DOI - 10.21037/jgo.2018.08.01

Subject(s) - medicine , esophageal adenocarcinoma , dysplasia , esophagus , barrett's esophagus , adenocarcinoma , gastroenterology , microrna , pathology , cancer , gene , biochemistry , chemistry

Diagnostic screening of premalignant esophageal lesions is hampered by the absence of biomarkers indicative of metaplastic and/or malignant transformation. The aim of this exploratory study was to investigate the potential use of miRNAs as biomarkers capable of identifying patients with (pre)malignant lesions: Barrett's esophagus (BE) metaplasia, high-grade dysplasia (HGD) or esophageal adenocarcinoma (EAC).

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