Exosomal markers (CD63 and CD9) expression and their prognostic significance using immunohistochemistry in patients with pancreatic ductal adenocarcinoma | Zendy

Moh’d Khushman | Zendy; Girijesh Kumar Patel | Zendy; Javier A. Laurini | Zendy; Arun Bhardwaj | Zendy; Kelly Roveda | Zendy; Robert Donnell | Zendy; Kelley Sherling | Zendy; Brittany Case | Zendy; Arthur E. Frankel | Zendy; Sachin Gopalkrishna Pai | Zendy; William R. Taylor | Zendy; Marcus Tan | Zendy; Meir Mizrahi | Zendy; Cindy Nelson | Zendy; Mary Wyatt | Zendy; Mary C. Patton | Zendy; Steven McClellan | Zendy; Seema Singh | Zendy; Bin Wang | Zendy; Ajay P. Singh | Zendy

Open Access

Exosomal markers (CD63 and CD9) expression and their prognostic significance using immunohistochemistry in patients with pancreatic ductal adenocarcinoma

Author(s) -

Moh’d Khushman,

Girijesh Kumar Patel,

Javier A. Laurini,

Arun Bhardwaj,

Kelly Roveda,

Robert Donnell,

Kelley Sherling,

Brittany Case,

Arthur E. Frankel,

Sachin Gopalkrishna Pai,

William R. Taylor,

Marcus Tan,

Meir Mizrahi,

Cindy Nelson,

Mary Wyatt,

Mary C. Patton,

Steven McClellan,

Seema Singh,

Bin Wang,

Ajay P. Singh

Publication year - 2019

Publication title -

journal of gastrointestinal oncology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.084

H-Index - 39

eISSN - 2219-679X

pISSN - 2078-6891

DOI - 10.21037/jgo.2018.07.02

Subject(s) - cd63 , immunohistochemistry , medicine , pancreatic ductal adenocarcinoma , microvesicles , pancreatic cancer , metastasis , clinical significance , oncology , pathology , tissue microarray , tumor progression , cancer , cancer research , microrna , biology , gene , biochemistry

Exosomes are important mediators of intercellular communications and play pivotal roles in cancer progression, metastasis and chemoresistance. CD63 and CD9 are widely accepted exosomal markers. In patients with pancreatic ductal adenocarcinoma (PDAC), positive correlation between CD9 expression and overall survival (OS) was reported. CD63 expression was conserved in all patients with no reported prognostic significance. This study explored the prognostic significance of CD63 and CD9 expression using immunohistochemistry (IHC) in patients with PDAC of mixed racial background.

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