Impact of sarcopenia on outcomes of locally advanced esophageal cancer patients treated with neoadjuvant chemoradiation followed by surgery | Zendy

Gilbert Z. Murimwa | Zendy; Puja Venkat | Zendy; William Jin | Zendy; Susan Leuthold | Zendy; Kujtim Latifi | Zendy; Khaldoun Almhanna | Zendy; José M. Pimiento | Zendy; Jacques-Pierre Fontaine | Zendy; Sarah E. Hoffe | Zendy; Jessica M. Frakes | Zendy

Open Access

Impact of sarcopenia on outcomes of locally advanced esophageal cancer patients treated with neoadjuvant chemoradiation followed by surgery

Author(s) -

Gilbert Z. Murimwa,

Puja Venkat,

William Jin,

Susan Leuthold,

Kujtim Latifi,

Khaldoun Almhanna,

José M. Pimiento,

Jacques-Pierre Fontaine,

Sarah E. Hoffe,

Jessica M. Frakes

Publication year - 2017

Publication title -

journal of gastrointestinal oncology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.084

H-Index - 39

eISSN - 2219-679X

pISSN - 2078-6891

DOI - 10.21037/jgo.2017.06.11

Subject(s) - medicine , sarcopenia , common terminology criteria for adverse events , radiation therapy , esophageal cancer , logistic regression , cancer , psoas muscles , cohort , chemoradiotherapy , radiology , surgery

Sarcopenia is an independent predictor of clinical outcomes in multiple gastrointestinal cancers. Total psoas area (TPA), as measured on a single cross-sectional CT image at the L4 vertebral body level, has been correlated with sarcopenia. We sought to evaluate whether TPA was predictive of acute grade ≥3 toxicity, pathologic response, and overall survival in patients with locally advanced esophageal cancer receiving tri-modality therapy.

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