miRNA-320 inhibits colitis-associated colorectal cancer by regulating the IL-6R/STAT3 pathway in mice | Zendy

Mengyao Wu | Zendy; Yuxin Luo | Zendy; Wen-Xiu Jia | Zendy; Dandan Wang | Zendy; Donglei Sun | Zendy; Jia Song | Zendy; Jing Wang | Zendy; Weiwei Niu | Zendy; Xiaolan Zhang | Zendy

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miRNA-320 inhibits colitis-associated colorectal cancer by regulating the IL-6R/STAT3 pathway in mice

Author(s) -

Mengyao Wu,

Yuxin Luo,

Wen-Xiu Jia,

Dandan Wang,

Donglei Sun,

Jia Song,

Jing Wang,

Weiwei Niu,

Xiaolan Zhang

Publication year - 2022

Publication title -

journal of gastrointestinal oncology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.084

H-Index - 39

eISSN - 2219-679X

pISSN - 2078-6891

DOI - 10.21037/jgo-22-237

Subject(s) - azoxymethane , stat3 , medicine , cancer research , colorectal cancer , microrna , carcinogenesis , western blot , proliferating cell nuclear antigen , colitis , stat protein , inflammatory bowel disease , cell growth , real time polymerase chain reaction , inflammation , cancer , microbiology and biotechnology , pathology , immunology , immunohistochemistry , biology , signal transduction , disease , biochemistry , genetics , gene

Colitis-associated colorectal cancer (CAC) is a serious complication of inflammatory bowel disease (IBD). microRNA-320 (miRNA-320) promotes intestinal mucosal barrier repair in IBD and inhibits tumor progression. However, the role of miRNA-320 in the progression of CAC remains to be defined. We studied the mechanisms of miRNA-320 in the progression of CAC in mice.

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