miR-4477b gene as a novel pathogenic mutation occurring during the transformation of colorectal adenoma into colorectal cancer | Zendy

Xiaoyu He | Zendy; Guohua Cheng | Zendy; Feng Xiao | Zendy; Lei Zhang | Zendy; Gang Jin | Zendy; Xin Zhao | Zendy; Ying Liu | Zendy; Juan Boo Liang | Zendy; Yarong Li | Zendy; Zhaoyu Liu | Zendy; Qiang Yuan | Zendy; Hongwei Ren | Zendy; Qilong Wu | Zendy; Jinrong Wu | Zendy; Lili Xue | Zendy; Jing Feng | Zendy; Zhihui Wang | Zendy; Yueming Xing | Zendy; Wei Wu | Zendy; Zheng Li | Zendy; Wei Dong | Zendy; Xiang Song | Zendy

Open Access

miR-4477b gene as a novel pathogenic mutation occurring during the transformation of colorectal adenoma into colorectal cancer

Author(s) -

Xiaoyu He,

Guohua Cheng,

Feng Xiao,

Lei Zhang,

Gang Jin,

Xin Zhao,

Ying Liu,

Juan Boo Liang,

Yarong Li,

Zhaoyu Liu,

Qiang Yuan,

Hongwei Ren,

Qilong Wu,

Jinrong Wu,

Lili Xue,

Jing Feng,

Zhihui Wang,

Yueming Xing,

Wei Wu,

Zheng Li,

Wei Dong,

Xiang Song

Publication year - 2021

Publication title -

journal of gastrointestinal oncology

Language(s) - English

Resource type - Journals

eISSN - 2219-679X

pISSN - 2078-6891

DOI - 10.21037/jgo-20-600

Subject(s) - colorectal adenoma , gene , colorectal cancer , gene family , sanger sequencing , genetics , kegg , gene mutation , medicine , biology , cancer research , cancer , genome , mutation , gene expression , transcriptome

Polyps may develop into colorectal cancer (CRC) after 10-20 years. The occurrence of polyps and tumors caused by somatic gene mutations is considered a main pathogenesis of CRC. Among all general patients with polyps or CRC, some had adenoma of varying degrees that were consistent with familial colorectal adenomas. A patient with CRC (the propositus) and his brothers and sister, all of whom had varying degrees of colorectal polyps showed different adenomas with different members in a family.

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