Increased expression of MCM4 is associated with poor prognosis in patients with hepatocellular carcinoma | Zendy

Ruinian Zheng | Zendy; Guowei Lai | Zendy; Rongfa Li | Zendy; Yanyan Hao | Zendy; Limin Cai | Zendy; Jun Jia | Zendy

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Increased expression of MCM4 is associated with poor prognosis in patients with hepatocellular carcinoma

Author(s) -

Ruinian Zheng,

Guowei Lai,

Rongfa Li,

Yanyan Hao,

Limin Cai,

Jun Jia

Publication year - 2021

Publication title -

journal of gastrointestinal oncology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.084

H-Index - 39

eISSN - 2219-679X

pISSN - 2078-6891

DOI - 10.21037/jgo-20-574

Subject(s) - hepatocellular carcinoma , human protein atlas , minichromosome maintenance , medicine , immunohistochemistry , cancer research , western blot , downregulation and upregulation , liver cancer , pathology , oncology , gene , biology , protein expression , genetics , proliferating cell nuclear antigen , eukaryotic dna replication

The minichromosome maintenance (MCM) protein complex is important for DNA replication. Moreover, the expression of specific MCM complex components has been associated with the survival of hepatocellular carcinoma (HCC) patients. However, the expression and functional roles of minichromosome maintenance complex component 4 (MCM4) in HCC development and progression have not yet been explored. We analyzed the expression and clinical significance of MCM4, including its association with liver cancer patient survival.

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