Open AccessN-myc downstream-regulated gene 2 promotes the protein stability of estrogen receptor beta via inhibition of ubiquitin-protein ligase E3A to suppress colorectal cancer
Author(s) -
Jun Zhu,
Yongzhi Lv,
Jun Hao,
Tingyu Shi,
Shuai Wang,
Ke Wang,
Xiaoyan Fan,
Yuan Guo,
Jian Zhang,
Jipeng Li
Publication year - 2020
Publication title -
journal of gastrointestinal oncology
Language(s) - English
Resource type - Journals
eISSN - 2219-679X
pISSN - 2078-6891
DOI - 10.21037/jgo-20-557
Subject(s) - ubiquitin ligase , medicine , ubiquitin , estrogen receptor beta , estrogen receptor , cancer research , colorectal cancer , estrogen receptor alpha , beta (programming language) , gene , cancer , biology , biochemistry , breast cancer , computer science , programming language
N-myc downstream-regulated gene 2 (NDRG2) and estrogen receptor beta (ERβ) both play key roles in cellular differentiation in colorectal cancer (CRC). Previous studies have demonstrated that ERβ co-locates with and directly transactivates NDRG2. However, the effect of NDRG2 on ERβ and its underlying mechanism remain largely unknown. Our aim of the study is to explore the effect of NDRG2 on ERβ and their contributions to progression of CRC.
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