Frequency-specific hypoglycemic effects of microwave irradiation on normal and streptozotocin-induced diabetic rats

Diabetes mellitus is a serious chronic metabolic disturbance which is characterized by obstinate elevation of blood glucose (BG) levels caused by inadequate insulin secretion and/or a peripheral resistance to insulin action (1). Treatment for diabetes is traditionally performed using oral anti-diabetic agents and subcutaneous insulin injection (2). Drug therapy for diabetes, however, is connected with adverse effects related to pharmacokinetic characteristics, hypoglycemia, secondary failures, skin reactions, gastrointestinal disturbances, rise in hepatic enzyme level and hematological disorders (1). Plantderived hypoglycemic agents are a significant alternative treatment for diabetes. For thousands of years, plant extracts have been widely used for treatment of diabetes as a complementary therapy (2-5). Original Article