The impact of alloantibodies directed against the second donor on long-term outcomes of repeat liver transplantation | Zendy

Qingyong Xu | Zendy; Brad Shrum | Zendy; Steve Leckie | Zendy; Anton Skaro | Zendy; Vivian C. McAlister | Zendy

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The impact of alloantibodies directed against the second donor on long-term outcomes of repeat liver transplantation

Author(s) -

Qingyong Xu,

Brad Shrum,

Steve Leckie,

Anton Skaro,

Vivian C. McAlister

Publication year - 2019

Publication title -

hepatobiliary surgery and nutrition

Language(s) - English

Resource type - Journals

eISSN - 2304-389X

pISSN - 2304-3881

DOI - 10.21037/hbsn.2019.01.14

Subject(s) - medicine , transplantation , liver transplantation , term (time) , physics , quantum mechanics

Despite reports that associate donor specific antibody (DSA) with rejection after liver transplantation, grafts are still allocated according to blood group (ABO) but not human leukocyte antigen (HLA) compatibility, possibly due to the absence of an easily discernible clinical association between adverse recipient outcome and DSA. Re-transplantation provides a test environment where the presence of preformed DSA is prevalent and its effect on outcome should be apparent.

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