Protective effect of Dachengqi decoction on the pancreatic microcirculatory system in severe acute pancreatitis by down-regulating HMGB-TLR-4-IL-23-IL-17A mediated neutrophil activation by targeting SIRT1 | Zendy

Jia Wang | Zendy; Yang Zou | Zendy; D.S. Chang | Zendy; Daqing Hong | Zendy; Jiong Zhang | Zendy

Open Access

Protective effect of Dachengqi decoction on the pancreatic microcirculatory system in severe acute pancreatitis by down-regulating HMGB-TLR-4-IL-23-IL-17A mediated neutrophil activation by targeting SIRT1

Author(s) -

Jia Wang,

Yang Zou,

D.S. Chang,

Daqing Hong,

Jiong Zhang

Publication year - 2021

Publication title -

gland surgery

Language(s) - English

Resource type - Journals

eISSN - 2227-8575

pISSN - 2227-684X

DOI - 10.21037/gs-21-655

Subject(s) - hmgb1 , acute pancreatitis , medicine , myeloperoxidase , pharmacology , in vivo , inflammation , immunology , biology , microbiology and biotechnology

Dachengqi decoction (DCQD), one of classic prescription of Chinese herbal medicine has been widely used in clinic to treat severe acute pancreatitis (SAP). The damage of pancreatic microcirculation plays key pathogenesis of SAP. However, little is known about the molecular pharmacological activity of DCQD on pancreatic microcirculation in SAP.

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