The impact of EGFR gene polymorphisms on the response and toxicity derived from neoadjuvant chemotherapy for breast cancer | Zendy

Yan Wang | Zendy; Ziping Wu | Zendy; Liheng Zhou | Zendy; Jinglu Lu | Zendy; Yaohui Wang | Zendy; Yanping Lin | Zendy; Shuguang Xu | Zendy; Yumei Ye | Zendy; Jing Peng | Zendy; Jie Zhang | Zendy; Wenjin Yin | Zendy; Jinsong Lu | Zendy

Open Access

The impact of EGFR gene polymorphisms on the response and toxicity derived from neoadjuvant chemotherapy for breast cancer

Author(s) -

Yan Wang,

Ziping Wu,

Liheng Zhou,

Jinglu Lu,

Yaohui Wang,

Yanping Lin,

Shuguang Xu,

Yumei Ye,

Jing Peng,

Jie Zhang,

Wenjin Yin,

Jinsong Lu

Publication year - 2020

Publication title -

gland surgery

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.643

H-Index - 22

eISSN - 2227-8575

pISSN - 2227-684X

DOI - 10.21037/gs-20-330

Subject(s) - medicine , breast cancer , oncology , genotype , single nucleotide polymorphism , chemotherapy , snp , logistic regression , odds ratio , cancer , gastroenterology , biology , gene , genetics

Neoadjuvant chemotherapy is usually used for treating locally advanced breast cancer. However, not all patients achieve pathologic complete response (pCR). In this study, we selected two epidermal growth factor receptor (EGFR) single nucleotide polymorphism (SNP) sites, rs1468727 and rs845552, to investigate the association between the genotypes and the response and toxicity derived from neoadjuvant chemotherapy for breast cancer.

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