Use of cardiac magnetic resonance to detect changes in metabolism in heart failure | Zendy

W. D. Watson | Zendy; Jack J. Miller | Zendy; Andrew Lewis | Zendy; Stefan Neubauer | Zendy; Damian J. Tyler | Zendy; Oliver J. Rider | Zendy; Ladislav Valkovič | Zendy

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Use of cardiac magnetic resonance to detect changes in metabolism in heart failure

Author(s) -

W. D. Watson,

Jack J. Miller,

Andrew Lewis,

Stefan Neubauer,

Damian J. Tyler,

Oliver J. Rider,

Ladislav Valkovič

Publication year - 2020

Publication title -

cardiovascular diagnosis and therapy

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.83

H-Index - 22

eISSN - 2223-3660

pISSN - 2223-3652

DOI - 10.21037/cdt.2019.12.13

Subject(s) - phosphocreatine , adenosine triphosphate , medicine , heart failure , nuclear magnetic resonance spectroscopy , metabolism , energy metabolism , spectroscopy , biochemistry , nuclear magnetic resonance , cardiology , chemistry , physics , quantum mechanics

The heart has a massive adenosine triphosphate (ATP) requirement, produced from the oxidation of metabolic substrates such as fat and glucose. Magnetic resonance spectroscopy offers a unique opportunity to probe this biochemistry: 31 Phosphorus spectroscopy can demonstrate the production of ATP and quantify levels of the transport molecule phosphocreatine while 13Carbon spectroscopy can demonstrate the metabolic fates of glucose in real time. These techniques allow the metabolic deficits in heart failure to be interrogated and can be a potential future clinical tool.

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