MiR-216a accelerates proliferation and fibrogenesis via targeting PTEN and SMAD7 in human cardiac fibroblasts | Zendy

Jinsong Tao | Zendy; Jingyi Wang | Zendy; Chunyu Li | Zendy; Weiwei Wang | Zendy; Hao Yu | Zendy; Jinhui Liu | Zendy; Xiangqing Kong | Zendy; Yan Chen | Zendy

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MiR-216a accelerates proliferation and fibrogenesis via targeting PTEN and SMAD7 in human cardiac fibroblasts

Author(s) -

Jinsong Tao,

Jingyi Wang,

Chunyu Li,

Weiwei Wang,

Hao Yu,

Jinhui Liu,

Xiangqing Kong,

Yan Chen

Publication year - 2019

Publication title -

cardiovascular diagnosis and therapy

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.83

H-Index - 22

eISSN - 2223-3660

pISSN - 2223-3652

DOI - 10.21037/cdt.2019.11.06

Subject(s) - pten , tensin , cancer research , microrna , pi3k/akt/mtor pathway , medicine , cell growth , protein kinase b , luciferase , cardiac fibrosis , clonogenic assay , microbiology and biotechnology , signal transduction , fibrosis , cell , biology , transfection , gene , biochemistry

Heart failure (HF) is a progressive disease with relatively poor prognosis and lacks effective therapy, and the discovery of dysregulated microRNAs (miRNAs) and their role in cardiac fibroblasts have provided a new avenue for elucidating the mechanism involved in HF.

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