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Protein kinase AMP-activated non-catalytic subunit gamma 2 gene ( PRKAG2 ) cardiac syndrome, caused by mutations in PRKAG2 , often shows myocardial hypertrophy and abnormal glycogen deposition in cardiomyocytes. However, it remains incurable due to a lack of a management guideline for treatment.

cardiovascular diagnosis and therapy

AKT-mTOR signaling-mediated rescue of PRKAG2 R302Q mutant-induced familial hypertrophic cardiomyopathy by treatment with β-adrenergic receptor (β-AR) blocker metoprolol