TXNIP knockout improves cardiac function after myocardial infarction by promoting angiogenesis and reducing cardiomyocyte apoptosis | Zendy

Jin Wang | Zendy; Xuejiao Wang | Zendy; Yan Zhang | Zendy; Wenjuan Shi | Zendy; Zhandong Lei | Zendy; Xiangying Jiao | Zendy

Open Access

TXNIP knockout improves cardiac function after myocardial infarction by promoting angiogenesis and reducing cardiomyocyte apoptosis

Author(s) -

Jin Wang,

Xuejiao Wang,

Yan Zhang,

Wenjuan Shi,

Zhandong Lei,

Xiangying Jiao

Publication year - 2022

Publication title -

cardiovascular diagnosis and therapy

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.83

H-Index - 22

eISSN - 2223-3660

pISSN - 2223-3652

DOI - 10.21037/cdt-21-732

Subject(s) - txnip , medicine , angiogenesis , vascular endothelial growth factor , thioredoxin interacting protein , protein kinase b , cardiac function curve , tunel assay , apoptosis , endocrinology , cancer research , biology , immunohistochemistry , heart failure , oxidative stress , thioredoxin , biochemistry , vegf receptors

Myocardial infarction (MI) is a common cause of death. Thioredoxin-interacting protein (TXNIP) expression increases after MI, and it exerts a negative regulatory effect on cardiac function after MI. Our study aimed to investigate the specific regulatory mechanism of TXNIP on angiogenesis and cardiomyocyte apoptosis after MI.

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