Association between CDK8 gene polymorphisms and dilated cardiomyopathy in a Chinese Han population | Zendy

Ran Zhang | Zendy; Yue Zhong | Zendy; Siyu Long | Zendy; Qin-Ni Yang | Zendy; Bin Zhou | Zendy; Li Rao | Zendy

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Association between CDK8 gene polymorphisms and dilated cardiomyopathy in a Chinese Han population

Author(s) -

Ran Zhang,

Yue Zhong,

Siyu Long,

Qin-Ni Yang,

Bin Zhou,

Li Rao

Publication year - 2021

Publication title -

cardiovascular diagnosis and therapy

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.83

H-Index - 22

eISSN - 2223-3660

pISSN - 2223-3652

DOI - 10.21037/cdt-21-323

Subject(s) - single nucleotide polymorphism , genotype , dilated cardiomyopathy , medicine , allele , genetics , ejection fraction , population , cardiomyopathy , gene , promoter , biology , heart failure , gene expression , environmental health

Dilated cardiomyopathy (DCM) is one of the most common types of cardiomyopathies. Various genes have been verified to be related to DCM, but the pathogenesis remains unclear. Cyclin-dependent-kinase 8 (CDK8), encoded by the CDK8 gene, is a transcriptional factor that regulates the phosphorylation of RNA polymerase II. It plays an important role in the transcription process and different signaling pathways. This study aimed to investigate the potential role of CDK8 gene polymorphisms in DCM susceptibility and prognosis in a Chinese Han population.

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