The interplay between HIF-1α and long noncoding GAS5 regulates the JAK1/STAT3 signalling pathway in hypoxia-induced injury in myocardial cells | Zendy

Yanwei Li | Zendy; Bing Song | Zendy; Jinlei Liu | Zendy; Yuqiang Li | Zendy; Jiebing Wang | Zendy; Na Liu | Zendy; Wei Cui | Zendy

Open Access

The interplay between HIF-1α and long noncoding GAS5 regulates the JAK1/STAT3 signalling pathway in hypoxia-induced injury in myocardial cells

Author(s) -

Yanwei Li,

Bing Song,

Jinlei Liu,

Yuqiang Li,

Jiebing Wang,

Na Liu,

Wei Cui

Publication year - 2021

Publication title -

cardiovascular diagnosis and therapy

Language(s) - English

Resource type - Journals

eISSN - 2223-3660

pISSN - 2223-3652

DOI - 10.21037/cdt-20-773

Subject(s) - viability assay , apoptosis , hypoxia (environmental) , gas5 , stat3 , downregulation and upregulation , flow cytometry , microbiology and biotechnology , cell , signal transduction , cancer research , biology , chemistry , long non coding rna , immunology , biochemistry , organic chemistry , oxygen , gene

Long non-coding RNA (lncRNA) GAS5 is associated with hypoxia-induced diseases whereas hypoxia-inducible factor-1α (HIF-1α) plays an important role in hypoxic injury of cells. The current study explores the regulatory functions of GAS5/HIF-1α which co-play in anoxic injury among rat cardiomyocytes H9C2 cells.

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