MiR-155 acts as an inhibitory factor in atherosclerosis-associated arterial pathogenesis by down-regulating NoxA1 related signaling pathway in ApoE−/− mouse | Zendy

Yu Tang | Zendy; Haoming Song | Zendy; Yuqin Shen | Zendy; Yian Yao | Zendy; Yunan Yu | Zendy; Guo-lian Wei | Zendy; Bangxiang Long | Zendy; Wenwen Yan | Zendy

Open Access

MiR-155 acts as an inhibitory factor in atherosclerosis-associated arterial pathogenesis by down-regulating NoxA1 related signaling pathway in ApoE−/− mouse

Author(s) -

Yu Tang,

Haoming Song,

Yuqin Shen,

Yian Yao,

Yunan Yu,

Guo-lian Wei,

Bangxiang Long,

Wenwen Yan

Publication year - 2021

Publication title -

cardiovascular diagnosis and therapy

Language(s) - English

Resource type - Journals

eISSN - 2223-3660

pISSN - 2223-3652

DOI - 10.21037/cdt-20-518

Subject(s) - neointima , transfection , vascular smooth muscle , blot , medicine , microbiology and biotechnology , small interfering rna , pathology , biology , gene , biochemistry , restenosis , smooth muscle , stent

To investigate the protective efficacy of miR-155 on down regulating NADPH oxidase isoform subunit A1 (NoxA1) gene expression, resulting in inhibition of VSMC migration and over proliferation and thus ameliorating the progression of arterial atherosclerosis in AS mouse model. Therefore, to further explore the regulatory effect of miR-155 on neointima formation in AS and locate potential anti-atherosclerosis target.

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